Common Drug a ‘Silver Bullet’ for Severe COVID-19 Patients, Israeli Scientists Find

(The Media Line) A readily available drug used to treat high lipid levels in the blood has been shown to “dramatically” help in the treatment of severe COVID-19 cases, according to a new study.

In the investigator-initiated interventional open-label clinical study, a research team led by Prof. Yaakov Nahmias, director of the Grass Center for Bioengineering at the Hebrew University of Jerusalem, administered 145 mg/day of TriCor (fenofibrate) to 15 patients hospitalized with severe COVID-19 over a period of 10 days and repeatedly monitored their disease progression.

“What we saw is that their inflammatory markers dropped very, very fast,” Nahmias told The Media Line. “Within 48 hours of receiving the drug, they simply didn’t have inflammation at all. There was no overreaction of the immune system as we usually expect to see in severe patients.”

The interventional clinical study was carried out on patients at Israel’s Barzilai Medical Center in the southern city of Ashkelon, with support from Abbott Laboratories. It was recently published on Research Square and is currently under peer review.

Within 48 hours of receiving the drug, they simply didn’t have inflammation at all. There was no overreaction of the immune system as we usually expect to see in severe patients.

The clinical outcomes of the study were dramatic: 14 out of 15 patients, or 93.3%, no longer required respiratory support after five to seven days of treatment, compared to 28.5% of patients in a historical control group. The final patient also eventually recovered and ended up being released some time later.

Though preliminary, the findings could very well indicate that TriCor is a “silver bullet” for the treatment of the virus, Nahmias said.

“Altogether, this is a very strong result,” he affirmed. “Usually, it takes several weeks to treat severe COVID-19 patients.”

“It’s highly statistically significant even though it’s a small study because we took markers every two days and we could actually show a dramatic effect on the time course of the disease,” he said.

All of the patients were above the age of 47, with the median age being 64. In addition, some had multiple comorbidities, such as diabetes, high blood pressure and obesity, among others.

Researchers recently found that COVID-19 causes an abnormal accumulation of lipids, which lead to severe inflammation in a process known as lipotoxicity. Fenofibrate, an FDA-approved drug since 1975, is typically used to treat symptoms of cholesterol and lower triglycerides in the blood.

While Nahmias and his team focused on severe cases, he believes fenofibrate could eventually also be used to treat moderate or mild cases and help speed up recovery.