Best Of The Web
“Judith Campisi has been a leading figure in the biology of aging since the early 1990s, when her research on the basic mechanisms of cancer revealed an unexpected finding—that cells enter a phase known as senescence that prevents them from becoming cancerous. More than 25 years later, the insight has led to a new kind of drug that may slow or modestly reverse human aging.
Campisi’s research is on the role of cellular senescence in cancer and other age-related diseases. Senescent cells undergo a transition into a twilight state where they are still active but no longer dividing; research by Campisi and others showed that this was a strategy to derail incipient cancers, which are characterized by runaway cell division and growth. But she and others also discovered that these senescent cells accumulate as we grow older, secreting an array of molecules that promote the tissue degradation associated with aging.
In the past five years, this insight has led to the pursuit of a new class of drugs known as senolytics, which eliminate senescent cells and, in animal experiments, restore more youthful characteristics. Campisi, a professor at the Buck Institute for Research on Aging in Novato, California, cofounded a company called Unity Biotechnology in 2011, which launched a human trial of its first senolytic drug last July.”
JJ Editor's Daily Picks
"Apple, Google, Starbucks, and companies like them all claim to be socially responsible, but the first element of social responsibility should be paying your fair share of tax."
"One problem with today’s polarized politics is that both parties don’t mind stretching constitutional limits to achieve their policy goals. Democrats cheered on Barack Obama’s legal abuses on immigration and so much more..."
"The Democratic Party has problems with Israel. But Reps. Ilhan Omar (Minn.) and Rashida Tlaib (Mich.), the new members of Congress who have attracted attention with toxic tweets and support for boycott, are not the main protagonists."
"Chicago Police sources now suggest he staged what he says was a racist and homophobic attack on him. Smollett vigorously denies it. Whatever the truth, it's a moment to reflect."
"In talmudic tort law.. the responsible party must transfer to the plaintiff an area of his best land of equivalent value- rather than a larger area of low-quality land. From the standpoint of classical economics, such a requirement is nonsensical."
"“Alexa, can I use you on Shabbat?” The journalist spoke into a small glass-and-metal device he held in his hand, which connected him to a distant supercomputer in a place known only as “the Cloud.”"
"Racial capitalism is the process of getting some sort of social or economic benefit from someone else’s racial identity. In the United States, this usually, though not always, involves white people benefiting from nonwhite racial identity."
"A gay French writer has lifted the lid on what he calls one of the world’s largest gay communities, the Vatican, estimating that most of its prelates are homosexually inclined..."
"I’ll state the obvious and say that much if not all of the reason my life hasn’t changed is that I’m not a parent. Children are life’s great timekeepers, and when you don’t live with any, you’re at the mercy of your own internal clock..."
"...cooking without recipes is a kitchen skill same as cutting vegetables into dice. It’s a way to improve your confidence in the kitchen and to make the act of cooking fun when sometimes it seems like a chore."
"Psychedelics have frequently been maligned in both the scientific community and mainstream culture. But new medical research and a more capacious understanding of the drugs have started to shift opinions."
"The story of angels stretches all the way back to the opening sections of the Book of Genesis. There, God posts cherubs as sentries at the gates of the Garden of Eden, following Adam and Eve’s expulsion. "