Best Of The Web
“It has been 200 years since Mary Shelley’s Frankenstein was published, and while scientists still haven’t figured out how to create a walking, talking complex life in a lab, they may be getting closer.
A growing number of researchers are mastering the creation of organoids: simplified, miniature versions of real human organs. These structures aren’t being harvested to make Frankenstein’s monster. Instead, they’re helping develop new drugs, and they are forcing the medical establishment to seriously consider the ethics of lab-grown life.
Developing pharmaceuticals is typically an expensive and risky process. Roughly 90 percent of drugs that make it to human trials are never submitted to the FDA for approval because they’re found to be unsafe or ineffective. Most estimates place the cost of developing a new drug at somewhere around $3 billion. Organoids, which are grown from human stem cells, may be able to remove some of the guesswork in patient trials.
“Researchers have gotten really good at curing diseases in mice, but unfortunately animal studies don’t really translate to human bodies,” says Kevin Costa, chief scientific officer at Novoheart, a stem cell biotechnology firm known for creating heart organoids. “There are differences in how cardiac muscle cells behave in rodents versus primates and humans. Consequently, one of the main reasons that drugs fail in clinical trials is because of cardiotoxicity, problems related to heart function.””
JJ Best Of The Web
"With the weakest of hands, an economy not much larger than that of Spain, and a GDP per capita several thousand dollars smaller than Malaysia, he has asserted massive negative influence over the globalized world."
"Scarcely hours after the titanic drubbing Democrats delivered to President Trump's GOP in the 2018 midterm elections, the 2020 presidential campaign began in deeply unwelcome earnest."
"US President Donald Trump recognized Jerusalem as Israel's capital exactly one year ago, breaking with decades of international consensus in the process. What was the historic move and what impact has it had?"
"With a decade’s worth of hits under her belt, Gaga is definitively one of the biggest stars in the world. Rolling Stone dubbed her the “Queen of Pop” in 2011."
"Have the scars of the housing bust turned us away from the American dream of homeownership? Survey data suggest otherwise.... We simply can’t afford to pursue that dream right now.'
"Even as phones and tablets extend their reach into daily life, a bigger screen remains supreme... the average American household watches nearly eight hours of television a day."
"Parties, private jets, and multimillion-dollar paintings: Art Basel Miami is part of a global network of art fairs that have transformed the worldwide art market."
"Dutton Books for Young Readers, a division of Penguin Random House, is releasing a series of tiny books that give the act of reading a studied whimsy."
"The presence was so disruptive, she added, that some children had a hard time when their parents left. Others were disappointed that their parents did not come for lunch."
"The kitchen — named after the Hebrew phrase “L’Chaim,” which means, “To Life!” — features a menu of Americanized Jewish food items such as pastrami on rye, potato knish with herb sour cream..."
"Life on the sprawling grasslands precipitated a shift from individualistic ways of living to more cooperative ways. This was the birth of what you might call “social intelligence,” and it changed the way our minds work."
"When you have headlines about “white privilege” and “evil white men,” Jews become the epitome of whiteness—except, of course, for neo-Nazis, who see Jews as hyper-integrationists."