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“It has been 200 years since Mary Shelley’s Frankenstein was published, and while scientists still haven’t figured out how to create a walking, talking complex life in a lab, they may be getting closer.
A growing number of researchers are mastering the creation of organoids: simplified, miniature versions of real human organs. These structures aren’t being harvested to make Frankenstein’s monster. Instead, they’re helping develop new drugs, and they are forcing the medical establishment to seriously consider the ethics of lab-grown life.
Developing pharmaceuticals is typically an expensive and risky process. Roughly 90 percent of drugs that make it to human trials are never submitted to the FDA for approval because they’re found to be unsafe or ineffective. Most estimates place the cost of developing a new drug at somewhere around $3 billion. Organoids, which are grown from human stem cells, may be able to remove some of the guesswork in patient trials.
“Researchers have gotten really good at curing diseases in mice, but unfortunately animal studies don’t really translate to human bodies,” says Kevin Costa, chief scientific officer at Novoheart, a stem cell biotechnology firm known for creating heart organoids. “There are differences in how cardiac muscle cells behave in rodents versus primates and humans. Consequently, one of the main reasons that drugs fail in clinical trials is because of cardiotoxicity, problems related to heart function.””
JJ Editor's Daily Picks
"Apple, Google, Starbucks, and companies like them all claim to be socially responsible, but the first element of social responsibility should be paying your fair share of tax."
"One problem with today’s polarized politics is that both parties don’t mind stretching constitutional limits to achieve their policy goals. Democrats cheered on Barack Obama’s legal abuses on immigration and so much more..."
"The Democratic Party has problems with Israel. But Reps. Ilhan Omar (Minn.) and Rashida Tlaib (Mich.), the new members of Congress who have attracted attention with toxic tweets and support for boycott, are not the main protagonists."
"Chicago Police sources now suggest he staged what he says was a racist and homophobic attack on him. Smollett vigorously denies it. Whatever the truth, it's a moment to reflect."
"In talmudic tort law.. the responsible party must transfer to the plaintiff an area of his best land of equivalent value- rather than a larger area of low-quality land. From the standpoint of classical economics, such a requirement is nonsensical."
"“Alexa, can I use you on Shabbat?” The journalist spoke into a small glass-and-metal device he held in his hand, which connected him to a distant supercomputer in a place known only as “the Cloud.”"
"Racial capitalism is the process of getting some sort of social or economic benefit from someone else’s racial identity. In the United States, this usually, though not always, involves white people benefiting from nonwhite racial identity."
"A gay French writer has lifted the lid on what he calls one of the world’s largest gay communities, the Vatican, estimating that most of its prelates are homosexually inclined..."
"I’ll state the obvious and say that much if not all of the reason my life hasn’t changed is that I’m not a parent. Children are life’s great timekeepers, and when you don’t live with any, you’re at the mercy of your own internal clock..."
"...cooking without recipes is a kitchen skill same as cutting vegetables into dice. It’s a way to improve your confidence in the kitchen and to make the act of cooking fun when sometimes it seems like a chore."
"Psychedelics have frequently been maligned in both the scientific community and mainstream culture. But new medical research and a more capacious understanding of the drugs have started to shift opinions."
"The story of angels stretches all the way back to the opening sections of the Book of Genesis. There, God posts cherubs as sentries at the gates of the Garden of Eden, following Adam and Eve’s expulsion. "