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“Of the 16 million American adults who live with depression, as many as one-quarter gain little or no benefit from available treatments, whether drugs or talk therapy. They represent perhaps the greatest unmet need in psychiatry. On Tuesday, the Food and Drug Administration approved a prescription treatment intended to help them, a fast-acting drug derived from an old and widely used anesthetic, ketamine.
The move heralds a shift from the Prozac era of antidepressant drugs. The newly approved treatment, called esketamine, is a nasal spray developed by Janssen Pharmaceuticals Inc., a branch of Johnson & Johnson, that will be marketed under the name Spravato. It contains an active portion of the ketamine molecule, whose antidepressant properties are not well understood yet.
“Thank goodness we now have something with a different mechanism of action than previous antidepressants,” said Dr. Erick Turner, a former F.D.A. reviewer and an associate professor of psychiatry at Oregon Health & Science University. “But I’m skeptical of the hype, because in this world it’s like Lucy holding the football for Charlie Brown: Each time we get our hopes up, the football gets pulled away.””
JJ Editor's Daily Picks
"Historic buildings and structures dating from the Byzantine era to the 20th century have been subjected to disastrous restorations in recent years here, prompting public outcry and fostering a cynical attitude toward planned projects."
"Fox News, normally the object of presidential praise on Twitter, was subjected to an unusual tweet-lashing over the weekend when the president went after three of its anchors."
"Opinion: I am not willing to cast a ballot for this current crop of scandal-mongers, gossips and PR-obsessed dilettantes who are tearing the country apart - don't we deserve better?"
"Listening to The Joe Rogan Experience is sort of like crashing an intense, intimate dinner party in which the only courses are whiskey and weed."
"At the Jewish Museum in London called “Jews, Money, Myth.” The show explores the ways in which Jews have been associated with money over the past 2,000 years."
"Footage of last week’s massacre in New Zealand, which the shooter streamed in real time via Facebook Live, quickly proliferated. The original 17-minute webcast was viewed fewer than 200 times and wasn’t immediately reported, Facebook says."
"When I hear that Jews are too powerful, my response is, we are not powerful enough. When I hear that AIPAC is too influential a lobby, I say it must become even more influential."
"Lost in migration: When Walter Benjamin fled France in 1940, he took a heavy black suitcase. Did it contain a typescript? Where is it now?"
"Someday my daughter will be asked if she wants to have a bat mitzvah. I’m inclined to let her make up her own mind... It's a lot of work to learn Hebrew, memorize parts of the Torah and prepare for a pressure-packed performance at such a young age."
"Tablet's Unorthodox Podcast: Gail Simmons, Shalom Auslander, Jill Kargman, Gil Hovav, and more on the Jewish foods that mean the most to them."
""Hitting someone is a foundational moral violation," Yale University Psychologist Paul Bloom wrote in a comment to the paper. "Indeed, these sorts of physical infractions are found to be morally wrong by the youngest babies we can test."
" Ilhan Omar in particular has garnered attention for tweets widely viewed by the Jewish community as trafficking in anti-Semitic tropes. The result has been the most media coverage of anti-Semitism in a decade..."