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“A Chinese researcher recently disrupted the CCR5 gene, which builds a protein that acts as an entryway that HIV uses to gain entry to T-cells, allegedly creating the world’s first genetically engineered baby. Chinese officials moved swiftly to condemn the work, and rightly so. Gene-edited babies should probably always be prohibited, not because of fears of creating inequalities and advantaged “super babies,” but because of the reality that editing an embryo is not medically necessary. These modifications occur around conception rather than treating a suffering person—always involving introducing risk, and thus testing the age-old medical admonition of primum non nocere, meaning “first, to do no harm.”
I have argued previously that it is better to enforce national, rather than international, regulation of gene modification tools such as CRISPR-Cas9, since strong regulatory powers such as the FDA exist (swift action by the Chinese supports this claim). In fact, the FDA has so far chosen to regulate CRISPR technology as a drug, rather than a device, which gives it more control over specific applications and uses, while Congress excludes money in its spending bill from being used by the FDA to review applications for editing germ-line or heritable code. Nevertheless, there is no law in the U.S. that outlaws gene-edited babies.
I believe that most modern nations have adequate controls to regulate gene-modified babies, but it is important to explain why there will always be an ambiguous health benefit in creating GMO humans. Consider that disabling the CCR5 gene is not a new idea since U.S. biotech companies are already pursuing a strategy of using a form of gene modification to disrupt this gene to protect T cells from HIV infection. One important difference to this form of prophylactic gene therapy is that when applying it to living human patients a doctor can trade off the risk of the disease versus the tiny risks that gene modification tools could unintentionally alter other genes or damage functional DNA in a patient. In the case of a gene-modified baby, one is only adding the risk of inserting the CRISPR molecules, compared to a hypothetical health status of a person-to-be. The risk calculation is speculative at best.”
JJ Editor's Daily Picks
"Have world leaders really got the will to bring peace to Yemen? We hear much about Yemen’s crisis, but far less about the hypocrisy of states fuelling the very conflict they condemn."
"No poll so far in our database has tested Trump against the relatively unknown Weld... Indeed, Weld seems like one of the weakest candidates that anti-Trump Republicans could put up in a national campaign. "
"An initiative by the mayor of Tiberias for the municipality to help provide public transportation on the Sabbath has caused the issue of the social status quo to the forefront of public discussion."
"Like “30 Rock,” “Kimmy Schmidt” obviously slanted leftward, but most always exhibited a similar eagerness to skewer politics more generally than just the GOP."
"Yes, we’re all overwhelmed with email. One recent survey suggested that the average American’s inbox has 199 unread messages. But volume isn’t an excuse for not replying."
"... platforms now have a stranglehold over publishers who, individually and even as a group, have little-to-no bargaining power when it comes to algorithmic changes, ad rates, and much else."
"[There's] a subgenre known as National Socialist black metal, which espouses neo-Nazi views and has been described by the Southern Poverty Law Center as aiming to recruit youth to white-supremacist causes."
"“The Ideas That Made America” by Jennifer Ratner-Rosenhagen is an anomaly in the genre. Its brevity is a point of pride, yet it aspires to do a little of everything."
"My wish is to die in my own bed, cared for by people I love—clean, comfortable and relatively free from pain. I hope to have time to say my goodbyes and give my final blessings."
"A diet for fast weight loss is a pipe dream. Many of us want to lose weight without making permanent changes, because we view thinness instead of health as a success."
"Opportunity casts a long shadow over all subsequent Mars rovers, setting a gold standard of JPL engineering. Customized versions of its mobility software are used on the rovers Curiosity and upcoming Mars 2020."
"Biblical scholarship has deepened our understanding of the Torah and at the same time challenges us to consider the implications of our declaring the Torah to be emet. What is emet and what does it mean to say that the Torah is emet?"