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Best Of The Web Science
“With nearly 50,000 drug overdose deaths from opioids last year and an estimated two million Americans addicted, the opioid crisis continues to rage throughout the U.S. This statistic must be contrasted with another: 25 million Americans live with daily chronic pain, for which few treatment options are available apart from opioid medications.
Opioid drugs like morphine and Oxycontin are still held as the gold standard when it comes to relieving pain. But it has become brutally obvious that opioids have dangerous side effects, including physical dependence, addiction and the impaired breathing that too often leads to death from an overdose. Researchers have long been searching for a drug that would relieve pain without such a heavy toll, with few results so far.
Now a study in monkeys published in Science Translational Medicine shows a new type of opioid drug met all the criteria on drug developers’ wish list. The findings even suggest that instead of causing addiction, the new compound might be used to curb addiction and pain all at once. The study was led by Mei-Chuan (Holden) Ko, a researcher at Wake Forest University, and medical chemist Nurulain Zaveri, founder of California-based Astraea Therapeutics. “They’ve got something here that’s really important,” says William Schmidt, a pharmaceutical consultantbased in Davis, Calif., who was not involved in the work. “I think the chances of a compound with these properties moving forward are high, and simultaneously pretty exciting.”
It sounds too good to be true – a nonaddictive opioid painkiller without lethal side effects. It could be a crucial tool in battling the opioid crisis, and it may soon be a reality.
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China's massive and rapid investments in Africa have been criticized by some as a form of economic colonialism. Others are just wondering why the West is missing out on the opportunity.
"For two years, Americans have tried to absorb the details of the 2016 attack — hacked emails, social media fraud, suspected spies — and President Trump’s claims that it’s all a hoax. The Times explores what we know and what it means."
Twenty-five years after Oslo, Israeli-Palestinian peace remains elusive. A mix of Leftist idealism and PLO rejectionism are to blame for taking the "process" out of the Peace Process.
"In recounting the life of alleged Mossad agent Ashraf Marwan, Ariel Vromen's disappointing film leaves the most interesting parts of the story off screen."
The tax cuts signed into law by President Donald Trump will add to the national debt. But they did succeed in one area: making rich people even richer.
"As Seen On TV" gadgets like the "sock slider" or a banana peeler are often mocked for being useless wastes of plastic. But for some individuals with disabilities, these gadgets make all the difference.
If SJWs often resemble religious fundamentalists, bell hooks is their highest prophet. Her work on gender and intersectionality have redefined American campuses, and her ideas are being put into action with religious fervor.
"It strikes me that we’re now suffering collectively from a “tyranny of the virtual,” since we find ourselves unable to look away from the screens that mediate not just print but, increasingly, reality itself."
Parents see it all the time. Young girls, confident and full of joy, become timid and shy around their tween and early teen years. A new book explores the sociological explanations for the loss in confidence.
How did a Chinese citrus fruit become the central symbol of one of Judaism's most important holidays? According to a new book by Rabbi David Moster, the Etrog wasn't always so important. For ancient Jews, any old fruit would do.
If IQ tests are any indication, Americans are getting stupider. Some think environmental factors could be to blame. Others say that it's our culture which is to blame for making us stupider.
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