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Best Of The Web Science
“With nearly 50,000 drug overdose deaths from opioids last year and an estimated two million Americans addicted, the opioid crisis continues to rage throughout the U.S. This statistic must be contrasted with another: 25 million Americans live with daily chronic pain, for which few treatment options are available apart from opioid medications.
Opioid drugs like morphine and Oxycontin are still held as the gold standard when it comes to relieving pain. But it has become brutally obvious that opioids have dangerous side effects, including physical dependence, addiction and the impaired breathing that too often leads to death from an overdose. Researchers have long been searching for a drug that would relieve pain without such a heavy toll, with few results so far.
Now a study in monkeys published in Science Translational Medicine shows a new type of opioid drug met all the criteria on drug developers’ wish list. The findings even suggest that instead of causing addiction, the new compound might be used to curb addiction and pain all at once. The study was led by Mei-Chuan (Holden) Ko, a researcher at Wake Forest University, and medical chemist Nurulain Zaveri, founder of California-based Astraea Therapeutics. “They’ve got something here that’s really important,” says William Schmidt, a pharmaceutical consultantbased in Davis, Calif., who was not involved in the work. “I think the chances of a compound with these properties moving forward are high, and simultaneously pretty exciting.”
It sounds too good to be true – a nonaddictive opioid painkiller without lethal side effects. It could be a crucial tool in battling the opioid crisis, and it may soon be a reality.
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"The bear market in crude has vastly different implications for the U.S. and euro zone. Also, fun with emerging markets and (in)efficient markets."
"That Trump would threaten California in the midst of this tragedy is, on its own, an act of cruelty. But his tweet was also plain wrong... there’s no dense forest surrounding the cities hit hardest by the fires."
"The integration of ultra-orthodox society into Israeli society at large and internal divisions within the ultra-orthodox world have caused many ultra-Orthodox Jews to vote for candidates in municipal elections who are not themselves ultra-orthodox.
"Each year, local governments spend nearly $100 billion to move headquarters and factories between states. It’s a wasteful exercise that requires a national solution."
"The futurist philosopher Yuval Noah Harari thinks Silicon Valley is an engine of dystopian ruin. So why do the digital elite adore him so?"
"Should the acquired item prove absolutely useless, as its original owner clearly felt it to be, there is always something else to do with it, provided one has ingenuity, a high tolerance for clutter, and, ideally, a range of demented enthusiasms."
"If it were true that novelists needed “quietude, time and space” to produce novels, Preston would be right to declare a state of crisis. But Bellow wrote his first novel while serving on a merchant marine ship during the Second World War."
"It’s an all too common story. Each Veterans Day, Americans recognize our active-duty military and veterans. We should also recognize their spouses."
"They’ve been maligned in nutrition circles for decades, with links to obesity, Type 2 diabetes and cardiovascular disease. But they’re also highly satisfying and provide many essential nutrients."
"Arguing that our current understanding cannot rule it out, Hawking, it seems, was cautiously optimistic. So where does this leave us? We cannot build a time machine today, but could we in the future?"
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